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金叶,教授,硕士生、博士生导师。主要从事新剂型与新型给药系统的研究、药物新剂型的透皮研究及其在化妆品领域的应用、中药大健康产品(化妆品、食品、医疗器械等)产品的开发。吉林省D类高层次人才。吉林大学与新西兰奥克兰大学联合培养博士,中药学博士后。药剂学学科后备带头人,吉林省企业“科创专员(科创副总)。
近5年,主持国家自然科学基金青年基金1项、吉林省科技厅项目3项、吉林省教育厅项目2项;以第一作者或通讯作者发表论文41篇,其中SCI论文20篇;申请国家发明专利6项,授权3项;获得吉林省科技进步二等奖1项。
多次指导学生在“挑战杯”、创新创业比赛、学科竞赛中,获得国家级特等奖、一等奖项、省级金奖等17个奖项,被评为第二届全国中医药高等院校大学生创新创业大赛优秀创新创业导师、第六届吉林省互联网+大学生创新创业大赛优秀指导教师。
本团队研究方向包括:新剂型与新型给药系统的建立、质量评价及体内外研究;动、植物外泌体的规模化制备、载释药技术、生物活性研究及产品开发;食品、化妆品、医疗器械等健康产品研发。指导及合作指导博士研究生4人,硕士研究生28人,其中获得国家级奖学金4人,校级奖学金18人/次。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg1.国家自然科学基金委员会,隐丹参酮调控SIRT5催化去琥珀酰化修饰抑制心肌细胞肥大的模式研究,24万元,2021/01-2023/12,结题,主持。
2.吉林省科技厅,刺五加抗衰老的作用机制研究及其高效纳米护肤品的开发,30万元,2021/07-2024/06,在研,主持。
3.吉林省教育厅,基于纳米缓控释技术的人参系列化妆品的产业化研究,2.5万元,2021/01-2022/12,结题,主持。
4.吉林省科技厅,银杏叶提取物类脂质体口服给药系统的构建及作用机制的研究,8万元,2017/01-2018/12,结题,主持。
5.吉林省科技厅,长白山灵芝抗衰老功效研究及化妆品的产业化开发,40万元,2022/01-2025/12,在研,主持。
6.吉林省教育厅,银杏叶提取物治疗阿尔兹海默病乙酰化修饰谱的构建,5万元,2017/01-2018/12,结题,主持。
一、科研论文 (第一作者或通讯作者)
1.Xinxin Yang , Ruiting Lin , Changzhuo Feng , Kang Qiyuan , Yu Peng , Deng Yongzhi , Ye Jin.Research Progress on Peptide Drugs for Type 2 Diabetes and the Possibility of Oral Administration, Pharmaceutics, Pharmaceutics 2024, 16, 1353.
2.Ye Jin, Qixuan Yu, Shuangyang Li, Tianli Chen* and Da Liu*. Application of seaweed polysaccharide in bone tissue regeneration. Frontiers in Marine Science, Volume 10 - 2023.
3.Xu Zheng, Dan Zhao, Ye Jin*, Yang Liu*, Da Liu*. Role of the NLRP3 inflammasome in gynecological diseaseBiomedicine & Pharmacotherapy. 166 (2023) 115393.
4.Ye Jin, Shuangyang Li, Qixuan Yu, Tianli Chen∗, Da Liu∗.Application of stem cells in regeneration medicine. MedComm. Volume4, Issue4,August 2023
5.Dimeng Song, Xiaoxue Fang, Zhiyuan Sun, Zhidong Qiu, Da Liu , Haoming Luo*, Ye Jin* and Donglu Wu*".Cryptotanshinone, a Potential SIRT3 Inhibitor, Suppresses Colorectal Cancer Proliferation in vitro and in vivo. Natural Product Communications, Volume 18(8): 1–12,2023
6.Shuangyang Li, Qixuan Yu, Hongpeng Li, Meiqi Chen, Ye Jin* and Da Liu*. Self-Assembled Peptide Hydrogels in Regenerative Medicine. Gels. 2023, 9(8), 653
7.Shuoxi Guo, Meiqi Chen, Shuangyang Li, Zijun Geng, Ye Jin * and Da Liu*. 17. Natural Products Treat Colorectal Cancer by Regulating miRNA. Pharmaceuticals, 2023, 16(8), 1122
8. Yuanyuan Jin, Da Liu, Zhen Lu, Lubing Yang, Jiangli Chen, Xuyan Zhou, Zhidong Qiu* ,Ye Jin*. Preparation and evaluation of liposomes and niosomes containing Ginseng saponins for antiphotoaging therapy. Frontiers in Bioengineering and Biotechnology, April 2022,Volume 10,Article 874827
9.Ye Jin, Tianjia Liu, Haoming Luo, Yangyang Liu* and Da Liu*.Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development. Frontiers in Oncology.March 2022,Volume 12,Article 848221
10.Zhaolin Tan, Jingfei Li, Haoming Luo, Yangyang Liu*, Ye Jin*. Plant extracellular vesicles: a novel bioactive nanoparticle for tumor therapy. Frontiers in Pharmacology, 29 September 2022.
11.Jialin Wei, Wen Zhang, Jie Li, Ye Jin* and Zhidong Qiu*.Application of Transgenic Pig Model in Biomedical Research: A Review Frontiers in Cell and Developmental Biology.17 October 2022
12.Ye Jin, Jianming Xing, Kejin Xu, Da Liu* and Yue Zhuo*.Exosomes in the tumor microenvironment: promoting cancer progression.Frontiers in Immunology, 06 October 2022.
13.Guorong Zhang, Xuyan Zhou, Shuang Hu, Ye Jin* and Zhidong Qiu*. Large Animal Models for the Study of Tendinopathy. Frontiers in Cell and Developmental Biology, 25 October 2022
14.Qirong Li, Dongxu Wang, Ziping Jiang, Rong Li, Tianyi Xue, Chao Lin, Yongzhi Deng, Ye Jin*, Baozhen Sun*.Advances of hydrogel combined with stem cells in promoting chronic wound healing. Frontiers in Chemistry, 28 November 2022
15.Ye Teng, Ming Zhu, Yuan Chi, Lijing Li* and Ye Jin*. Can G-quadruplex become a promising target in HBV therapy? Frontiers in Immunology, 2022.1091873
16.Shuang Hu, Lulu Huo, Jing He, Ye Jin*, Yongzhi Deng* and Da Liu*. Ginseng Glycoprotein and Ginsenoside Facilitate Anti UV Damage Effects in Diabetic Rats. Frontiers in Pharmacology, 2022.1075594
17. Xuyan Zhou, Haiying Lian, Hongpeng Li, Meiling Fan*, Wei Xu* and Ye Jin*. Nanotechnology in cervical cancer immunotherapy: therapeutic vaccines and adoptive cell therapy. Frontiers in Pharmacology. 2022.1065793
18.Lijuan Wang, Henan Xu, Lili Weng, Jin Sun, Ye Jin* and Chunping Xiao*. Activation of Cancer Immunotherapy by Nanomedicine.Frontiers in Pharmacology, 2022.1041073
19.Ye Jin, Xue Meng, Zhidong Qiu, Yanping Su, Peng Yu*, Peng Qu* Anti-tumor and anti-metastatic roles of cordycepin, one bioactive compound of Cordyceps militaris, Saudi Journal of Biological Sciences, 25 (2018) 991–995
20.陈江丽,邱智东,金媛媛,周栩妍,李弘鹏,刘达,金叶*。水飞蓟素脂质体的制备、质量评价及其对 HaCaT 细胞增殖和摄取的影响。中草药,2022年6月第53卷第12期。
21.鹿禛,邱智东,王蕾,陈江丽,金叶*。人参总皂苷对皮肤细胞的修复作用机制研究。吉林中医药,2020 Vol.40 No.4, 338-341.
22.刘达,董金香,金叶*。大学生创新实验项目对中药类学生创新能力培养的作用。中国教育技术装备,2017.9。
二、专利
1. 一种添加人参类脂质体的抗氧化功能眼霜及其制备方法
2. 一种添加人参类脂质体的抗氧化功能爽肤水及其制备方法
3. 一种刺五加糖蛋白的提取方法和应用
4. 一种类脂质体及其制剂的制备方法
5. 灵芝糖肽及其制备方法、应用以及灵芝糖肽微乳和面霜
6. 一种郁金糖蛋白水凝胶贴及其制备方法和应用
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