导师风采
王洋
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  • 副研究员
  • 导师类别:硕士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士
  • 单位:长春中医药大学(吉林省人参科学研究院)

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  • 所属院系:药学院
  • 硕导专业:中药分析学(学术型)、护理学(学术型)、护理(专业型)
  • 邮箱 : wangyang@ccucm.edu.cn
  • 工作电话 : 0431-89989835

个人简介

Personal Profile

        王洋,博士,副研究员,主要从事中药质谱分析和代谢组学相关研究。主持国家和省部级科研项目3项。以第一作者和通讯作者发表SCI学术论文40余篇,主编专著1部。获吉林省科技进步一等奖1项,吉林省自然科学奖二等奖1项,吉林省自然科学学术成果一等奖1项,二等奖1项。


  • 研究方向Research Directions
1. 中药分析新方法与新技术研究, 2. 基于液质联用的代谢组学方法开发及应用研究
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
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个人简历

教育背景 

2005年9月-2012年6月 长春中医药大学 学士 硕士 

2015年8月-2018年7月 澳门大学 中药质量研究国家重点实验室 博士 


工作经历 

2013年5月-至今 长春中医药大学 研究实习员 助理研究员 副研究员 

2020年1月-2022年1月 澳门大学 中药质量研究国家重点实验室 博士后 


科研项目

1. 国家自然科学基金,82104366,基于类花生酸类物质代谢网络调控的蒺藜皂苷抗缺血性中风的作用机制研究,主持。 

2. 吉林省科技厅项目,20210101426JC,基于花生四烯酸及其代谢产物的拟靶向分析的中药寒热药性研究,主持。 

3. 吉林省科技厅项目,20220505047ZP,色谱-质谱大型仪器在中医药领域的开放共享与服务,主持。 


代表性论文

1. Zhao, Liang; Wang, Shuyue; Xu,Xiaohang; Guo, Wenjun; Yang, Jingxuan; Liu, Yue; Xie, Shengxu; Piao, Guangchun;Xu, Tunhai*; Wang, Yang*; Xu, Yajuan. Integrated metabolomics and network pharmacology to reveal the lipid-lowering mechanisms of Qizha Shuangye granules in hyperlipidemic rats. Journal of the Science of Food and Agriculture. 2024, 104, 3265-3274.

2. Yang, Jingxuan; Guo, Wenjun;Xu, Xiaohang; Zhao, Liang; Xu, Yajuan; Wang, Yang*. Analysis of fatty acid in biological samples using liquid chromatography–quadrupole-Orbitrap mass spectrometry under parallel reaction monitoring mode. Journal of Analysis and Testing. 2024, 8, 210-217.

3. Wang, Yang*. Recent advances in the application of direct analysis in real time-mass spectrometry (DART-MS) in food analysis. Food Research International. 2024, 188, 114488.

4. Sun, Yuanhe; Han, Yuqing; Guo,Wenjun; Xu, Xiaohang; Zhao, Liang; Yang, Jingxuan; Li, Lixin*; Wang, Yang*; Xu,Yajuan. Multi-omics analysis of lung tissue metabolome and proteome reveals the therapeutic effect of Shegan Mahuang Decoction against asthma in rats. Journal of Ethnopharmacology. 2024, 322, 117650.

5. Zhang, Hongming; Guo, Wenjun;Li, Xingxing; Xie, Shengxu; Liu, Yue; Chen, Geng; Wang, Yang*; Xu, Yajuan*.Supplementation with Tribulus Terrestris extract exhibits protective effects on MCAO rats via modulating inflammation-related metabolic and signaling pathways. ACS Omega. 2023, 8, 2306-2314.

6. Wang, Yang*; Liu, Shuying.Recent application of direct analysis in real time mass spectrometry in plantmaterials analysis with emphasis on traditional Chinese herbal medicine. Mass Spectrometry Reviews. 2023, n/a, doi:https://doi.org/10.1002/mas.21866.

7. Wang, Yang*; Liu, Shuying.BoxCar data-dependent acquisition improves the MS/MS coverage in liquid chromatography-mass spectrometry-based metabolomics analysis. Arabian Journal of Chemistry. 2023, 16, 105325.

8. Xu, Dandan; Wang, Yang*; Guo,Wenjun; Li, Xingxing; Liu, Yue; Han, Yuqing; Zhang, Hongming; Wei, Qiyan; Wang,Yongsheng*; Xu, Yajuan*. LC-MS-based multi-omics analysis of brain tissue for the evaluation of the anti-ischemic stroke potential of Tribulus terrestris L. fruit extract in MCAO rats. Arabian Journal of Chemistry. 2022, 15, 104297.

9. Wei, Wei; Liu, Liming; Liu,Xiaokang; Tao, Ye; Gong, Jiyu*; Wang, Yang*; Liu, Shuying. Black ginseng protects against Western diet‐induced nonalcoholic steatohepatitis by modulating the TLR4/NF‐κB signaling pathway in mice. Journal of Food Biochemistry. 2022,e14432.

10. Han, Yuqing; Guo, Wenjun; Li,Xingxing; Xu, Xiaohang; Yang, Jingxuan; Xie, Shengxu; Liu, Yue; Zhang,Hongming; Wang, Yang*; Xu, Yajuan*. LC-MS-based metabolomics reveals the in vivo effect of Shegan Mahuang Decoction in an OVA-induced rat model of airway hyperresponsiveness. Molecular Omics. 2022, 18, 957-966.

11. Wang, Yang; Guo, Wenjun; Xie,Shengxu; Liu, Yue; Xu, Dandan; Chen, Geng; Xu, Yajuan*. Multi-omics analysis of brain tissue metabolome and proteome reveals the protective effect of gross saponins of Tribulus terrestris L. fruit against ischemic stroke in rat. Journal of Ethnopharmacology. 2021, 278, 114280.

12. Guo, Yunlong; Chi, Hongyue; Liu, Xiaokang; Sun, Xiuli; Wang, Yang*; Liu, Shuying. Rapid characterization of Schisandra species by using direct analysis in real time mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2021, 192, 113648.

13. Li, Lele; Wang, Yang*; Liu, Shuying. Application of pseudotargeted method combined with multivariate statistical analysis for the quality assessment of traditional Chinese medicine preparation, Sanhuang Tablet as a case. Analytical Bioanalytical Chemistry. 2020, 412, 5863-5872.

14. Li, Lele; Ma, Li; Guo, Yunlong; Liu, Wenlong; Wang, Yang*; Liu, Shuying. Analysis of oligosaccharides from Panax ginseng by using solid-phase permethylation method combined with ultra-high-performance liquid chromatography-Q-Orbitrap/mass spectrometry. Journal of Ginseng Research. 2020, 44, 775-783.

15. Guo, Wenjun; Wang, Yang*; Fan,Meiling; Xie, Shengxu; Zhao, Hongyu; Wang, Jifeng; Liu, Yue; Xu, Dongming; Xu,Yajuan*. Integrating metabolomics and network pharmacology to explore the protective effect of gross saponins of Tribulus terrestris L. fruit against ischemic stroke in rat. Journal of Ethnopharmacology. 2020, 263, 113202.

16. Wang, Yang; Feng, Ruibing; He, Chengwei; Su, Huanxing; Ma, Huan; Wan, Jian-Bo*. An integrated strategy to improve data acquisition and metabolite identification by time-staggered ionlists in UHPLC/Q-TOF MS-based metabolomics. Journal of Pharmaceutical and Biomedical Analysis. 2018, 157, 171-179.

17. Wang, Yang; Feng, Ruibing;Wang, Ruibing; Yang, Fengqing; Li, Peng; Wan, Jian-Bo*. Enhanced MS/MS coverage for metabolite identification in LC-MS-based untargeted metabolomics by target-directed data dependent acquisition with time-staggered precursor ion list. Analytica Chimica Acta. 2017, 992, 67-75.

18. Wang, Yang; Zhou, Shujun; Wang,Meng; Liu, Shuying; Hu, Yuanjia; He, Chengwei; Li, Peng; Wan, Jian-Bo*.UHPLC/Q-TOFMS-based metabolomics for the characterization of cold and hot properties of Chinese materia medica. Journal of Ethnopharmacology. 2016, 179, 234-242.

19. Wang, Yang; Liu, Fang; Li, Peng; He, Chengwei; Wang, Ruibing; Su, Huanxing; Wan, Jian-Bo*. An improved pseudotargeted metabolomics approach using multiple ion monitoring with time-staggered ion lists based on ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Analytica Chimica Acta. 2016, 927, 82-88.

20. Wang, Yang; Liu, Shuying; Hu,Yuanjia; Li, Peng; Wan, Jian-Bo*. Current state of the art of mass spectrometry-based metabolomics studies–a review focusing on wide coverage, high throughput and easy identification. RSC Advances. 2015, 5, 78728-78737.

21. Wang, Yang; Ma, Li; Sun, Yi;Yang, Liman; Yue, Hao; Liu, Shuying*. Metabonomics study on the hot syndrome of traditional Chinese medicine by rapid resolution liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry. Archives of Pharmacal Research. 2014, 37, 899-906.

22. Wang, Yang; Li, Chunmei; Huang,Liang; Liu, Li; Guo, Yunlong; Ma, Li*; Liu, Shuying*. Rapid identification of traditional Chinese herbal medicine by direct analysis in real time (DART) mass spectrometry. Analytica Chimica Acta. 2014, 845, 70-76.


专利&专著

1. 发明专利名称:一种用于非靶向代谢组学研究的靶向数据分析方法,发明人:王洋,专利号:ZL202410485904.1,授权公告号:CN118067908B.

2. 王洋 主编,代谢组学方法与技术,北京:化学工业出版社,2025.

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