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陈士林，中国工程院院士，中国医学科学院学部委员，成都中医药大学首席教授、香港浸会大学荣誉教授、为教育部“长江学者和创新团队计划”创新团队负责人、中国质量协会中药分会会长。兼任日本东京药科大学客座教授。担任APSB、《药学学报》等刊副主编。在Nature，Nature Plants, Nature Communications等国内外期刊发表论文500余篇，论文被引用3.6万次，H指数88 (Google Scholar)，入选Elsevier全球终身科学影响力榜单。荣获全国创新争先奖章。
长期从事中药研究，创建中药材生态适宜性与数值区划专业平台，从生态学角度解决我国中药材应该“在哪里种”的难题，2006年获国家科技进步二等奖。完成并编著《中国中药材产地生态适宜性数值区划》，避免中药材盲目引种栽培；创建了基于ITS2的中草药DNA条形码鉴定方法体系，完成专著《中国药典中药材DNA条形码标准序列》，从基因层面解决千百年来中药材物种真伪鉴定难题，开辟中药鉴定新领域，重点解决中药品质等影响临床用药安全有效的核心问题，被评为2016中国十大医学进展；创立“本草基因组学”学科，通过全基因组解析提出灵芝为首个中药基原药用模式真菌，被Nature China选为中国最佳研究亮点推介。完成并发表人参、丹参、赤芝、菊花、卷柏、穿心莲、紫芝、紫苏、黄连、红豆杉等药用植物全基因组图谱和相关组学研究，成功培育并获批31个中药材新品种证书或良种证书。主编《本草基因组学》并由科学出版社出版，列为全国高等医药院校规划教材；出版《药用植物分子遗传学》，奠定药用植物分子遗传学基础；获国家科技进步二等奖3项等。
以中医药传承创新为基础，团队现聚焦于人类全基因组泛受体与药物效应多样性之间的关系，提出“药靶同筛”中药研发新思路；致力于打造以GPCR为核心的人类全基因组泛受体中药筛选与评价平台；依托成都中医药大学高性能计算平台建立GPCR-omics数据库，通过多组学与大数据技术的协同应用助力高通量药物分子及相应GPCR筛选，致力于天然产物配体发现及药物评价。拟创新构建中药研发底层核心技术，依托药物筛选与评价平台解决产业核心问题。
近期主要论文：
1. Liang Leng，Zhichao Xu，Bixia Hong，Binbin Zhao，Ya Tian，Can Wang，Lulu Yang，Zhongmei Zou，Lingyu Li，Ke Liu，Wanjun Peng，Jiangning Liu，Zhoujie An，Yalin Wang，Baozhong Duan，Zhigang Hu，Chuan Zheng，Sanyin Zhang，Xiaodong Li，Maochen Li，Zhaoyu Liu，Zenghao Bi，Tianxing He，Baimei Liu，Huahao Fan，Chi Song，Yigang Tong，Shilin Chen*. Cepharanthine analogs mining and genomes of Stephaniaaccelerate anti-coronavirus drug discovery. Nature Communications. 2024 Feb20;15(1):1537.
2. Wei Sun，Qinggang Yin，Huihua Wan，Ranran Gao，Chao Xiong，Chong Xie，Xiangxiao Meng，Yaolei Mi，Xiaotong Wang，Caixia Wang，Weiqiang Chen，Ziyan Xie，Zheyong Xue，Hui Yao，Peng Sun，Xuehua Xie，Zhigang Hu，David R Nelson，Zhichao Xu，Xinxiao Sun，Shilin Chen*. Characterization of the horse chestnut genome reveals theevolution of aescin and aesculin biosynthesis. Nature Communications. 2023 Oct13;14(1):6470.
3. Wei Chen，Chi Song，Liang Leng，Sanyin Zhang，Shilin Chen*.The Application of Artificial Intelligence Accelerates GProtein-Coupled Receptor Ligand Discovery[J].Engineering,2024,32(1):19-29.
4. Sijie Sun，Xiaofeng Shen，Yi Li，Ying Li，Shu Wang，Rucan Li，Huibo Zhang，Guoan Shen，Baolin Guo，Jianhe Wei，Jiang Xu，Benoit St-Pierre，Shilin Chen*，Chao Sun. Single-cell RNA sequencing provides a high-resolutionroadmap for understanding the multicellular compartmentation of specializedmetabolism. Nature plants,2023 Jan;9(1):179-190.
5. Baosheng Liao，Xiaofeng Shen，Li Xiang，Shuai Guo，Shiyu Chen，Ying Meng，Yu Liang，Dandan Ding，Junqi Bai，Dong Zhang，Tomasz Czechowski，Yi Li，Hui Yao，Tingyu Ma，Caroline Howard，Chao Sun，Haitao Liu，Jiushi Liu，Jin Pei，Jihai Gao，Jigang Wang，Xiaohui Qiu，Zhihai Huang，Hongyi Li，Ling Yuan，Jianhe Wei，Ian Graham，Jiang Xu，Boli Zhang，Shilin Chen*. Allele-aware chromosome-level genome assembly ofArtemisia annua reveals the correlation between ADS expansion and artemisininyield. Mol Plant. 2022 Aug 1;15(8):1310-1328.
6. Yujun Zhang，Qi Shen，Liang Leng，Dong Zhang，Sha Chen，Yuhua Shi，Zemin Ning，Shilin Chen*. Incipient diploidization of the medicinal plant Perilla within10,000 years，Nature Communications volume12,Article number:5508(2021).
7. Shilin Chen*，Jiang Xu，Chang Liu，Yingjie Zhu，David R Nelson，Shiguo Zhou，Chunfang Li，Lizhi Wang，Xu Guo，Yongzhen Sun，Hongmei Luo，Ying Li，Jingyuan Song，Bernard Henrissat，Anthony Levasseur，Jun Qian，Jianqin Li，Xiang Luo，Linchun Shi，Liu He，Li Xiang，Xiaolan Xu，Yunyun Niu，Qiushi Li，Mira V Han，Haixia Yan，Jin Zhang，Haimei Chen，Aiping Lv，Zhen Wang，Mingzhu Liu，David C Schwartz，Chao Sun. Genome sequence of the model medicinal mushroomGanoderma lucidum. Nature Communications. 2012 Jun 26;3:913.
8. Yifei Liu，Bo Wang，Shaohua Shu，Zheng Li，Chi Song，Di Liu，Yan Niu，Jinxin Liu，Jingjing Zhang，Heping Liu，Zhigang Hu，Bisheng Huang，Xiuyu Liu，Wei Liu，Liping Jiang，Mohammad Murtaza Alami，Yuxin Zhou，Yutao Ma，Xiangxiang He，Yicheng Yang，Tianyuan Zhang，Hui Hu，Michael S Barker，Shilin Chen*，Xuekui Wang，Jing Nie. Analysis of the Coptis chinensis genome reveals thediversification of protoberberine-type alkaloids. Nature Communications. 2021Jun 2;12(1):3276.
9. Shilin Chen，Jingyuan Song， Chao Sun， Jiang Xu，Yingjie Zhu，Rob Verpoorte，Tai Ping Fan.Herbal genomics: Examining the biology oftraditional medicines. Science 2015,347(6219),S27-S29.
10. China Plant BOL Group，De-Zhu Li，Lian-Ming Gao，Hong-Tao Li，Hong Wang，Xue-Jun Ge，Jian-Quan Liu，Zhi-Duan Chen，Shi-Liang Zhou，Shi-Lin Chen，Jun-Bo Yang，Cheng-Xin Fu，Chun-Xia Zeng，Hai-Fei Yan，Ying-Jie Zhu，Yong-Shuai Sun，Si-Yun Chen，Lei Zhao ，Kun Wang，Tuo Yang，and Guang-Wen Duan.Comparativeanalysis of a large dataset indicates that internal transcribed spacer (ITS)should be incorportated into the core barcode for seed plants. PNAS,2011,108:19641-19646.
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