指导及合作指导；

       博士研究生4人，硕士研究生16人，其中获国家级奖学金3人，优秀研究生3人，研究生学术之星3人。以学生为第一作者发表SCI论文18篇。师生共创成立大学生创新创业公司，研发推广人参酒、人参冰酒。获吉林省优秀青年人才创新创业团队，全国中医药院校大学生创新创业大赛最具投资价值奖。

1.国家自然科学基金委员会，82405038，人参皂苷Rb2调控色氨酸代谢介导AhR/IL-22/MAPK信号通路发挥免疫调节作用的机制研究, 2025-01至2027-12, 30万元, 在研，主持

2.吉林省科学技术厅, 自由探索项目,YDZ1202501ZYTS745,林下参原人参二醇型皂苷通过“肠道菌群-色氨酸代谢-免疫”信号轴发挥补气功效的机制研究,2025-01至2027-12, 10万元, 在研，主持

3.吉林省科学技术厅, 技术创新引导, 20220401126YY, 人参抗衰祛皱系列化妆品的产业化开发, 2022-07 至 2025-06, 50万元, 在研, 主持

4. 长春中医药大学2023年青年优秀学科骨干培养项目，高载药量人参皂苷Rg3纳米晶固体分散体系的构建及口服吸收机制的研究，2023-01至2024-12，8万元，结题，主持

5.广州通泽医疗科技有限公司，横向课题，人参糖肽成分制备及功效实验验证项目，2022-09至2024-09，22万元，结题，主持

6.吉林省科学技术厅, 医药健康领域, 20210204046YY, 基于中医验方的创新中药-通腑泻下颗粒的临床 前研究, 2021-07 至 2024-06, 40万元, 结题, 主持

7.白山市科学技术局，医药健康产业，QK2021012，百合规范化种植基地建设与示范，2021至2022-09，5万元，结题，主持

8. 吉林省人力资源和社会保障厅，吉林省博士后科研人员择优资助项目，肠道菌群代谢物调控NF-κB介导的黄芩调节免疫炎症作用的机制研究，2021-09至2022-08，10万元，结题，主持

9.吉林省教育厅, 基础研究, JJKH20181270KJ, 人参皂苷Rb3在人肠内菌中代谢机制的研究, 2018-01 至 2019-12, 2.5万元, 结题, 主持

10.吉林省科学技术厅，医药健康产业，2020157，改善睡眠功能保健食品的研发，2017-01至2019-12，160.0万元，结题，主持

11.吉林省中医药管理局，2017161，参景五味颗粒抗疲劳保健食品开发，2017-01至2018-12，1万元，结题，主持

1.国家自然科学基金委员会，82405038，人参皂苷Rb2调控色氨酸代谢介导AhR/IL-22/MAPK信号通路发挥免疫调节作用的机制研究, 2025-01至2027-12, 30万元, 在研，主持

2.吉林省科学技术厅, 自由探索项目,YDZ1202501ZYTS745,林下参原人参二醇型皂苷通过“肠道菌群-色氨酸代谢-免疫”信号轴发挥补气功效的机制研究,2025-01至2027-12, 10万元, 在研，主持

3.吉林省科学技术厅, 技术创新引导, 20220401126YY, 人参抗衰祛皱系列化妆品的产业化开发, 2022-07 至 2025-06, 50万元, 在研, 主持

4. 长春中医药大学2023年青年优秀学科骨干培养项目，高载药量人参皂苷Rg3纳米晶固体分散体系的构建及口服吸收机制的研究，2023-01至2024-12，8万元，结题，主持

5.广州通泽医疗科技有限公司，横向课题，人参糖肽成分制备及功效实验验证项目，2022-09至2024-09，22万元，结题，主持

6.吉林省科学技术厅, 医药健康领域, 20210204046YY, 基于中医验方的创新中药-通腑泻下颗粒的临床 前研究, 2021-07 至 2024-06, 40万元, 结题, 主持

7.白山市科学技术局，医药健康产业，QK2021012，百合规范化种植基地建设与示范，2021至2022-09，5万元，结题，主持

8. 吉林省人力资源和社会保障厅，吉林省博士后科研人员择优资助项目，肠道菌群代谢物调控NF-κB介导的黄芩调节免疫炎症作用的机制研究，2021-09至2022-08，10万元，结题，主持

9.吉林省教育厅, 基础研究, JJKH20181270KJ, 人参皂苷Rb3在人肠内菌中代谢机制的研究, 2018-01 至 2019-12, 2.5万元, 结题, 主持

10.吉林省科学技术厅，医药健康产业，2020157，改善睡眠功能保健食品的研发，2017-01至2019-12，160.0万元，结题，主持

11.吉林省中医药管理局，2017161，参景五味颗粒抗疲劳保健食品开发，2017-01至2018-12，1万元，结题，主持

一、科研论文 （第一作者或通讯作者）

(1) Zhang M, Ma L, Luo J, Ren T, Liu S, Pan L, Bao Y, Li F, Dai Y, Pi Z, Yue H, Zheng F. Low-Medium Polarity Ginsenosides from Wild Ginseng Improves Immunity by Activating the AhR/MAPK Pathway through Tryptophan Metabolism Driven by Gut Microbiota. J Agric Food Chem. 2024 Nov 27;72(47):26142-26154.

(2) Wu Y, Liu S, Ren T, Ma L, Luo J, Zhang M, Li F, Dai Y, Zheng F, Pi Z, Yue H. Ginseng fermentation solution affects the gut microbiota in zebrafish with alcoholic liver disease via PI3K/Akt pathway. Phytomedicine. 2024 Feb 27;128:155495.

(3) Ma L, Wu Y, Luo J, Li F, Zhang M, Cai Y, Dai Y, Pi Z, Zheng F*, Yue H*. Identifying the active compounds and mechanism of action of TongFu XieXia Decoction for treating intestinal obstruction using network pharmacology combined with ultra-high performance liquid chromatography - quadrupole - orbitrap mass spectrometry. Rapid Commun Mass Spectrom. 2024 Jan 30;38(2):e9664.

(4) Fangtong Li, Meiyu Zhang, Yongyu Cai, Yongxi Wu, Yizhu Wang, Jing Luo, Zifeng Pi, Yulin Dai, Fei Zheng*, Hao Yue*.Total ginsenoside wild ginseng root improves spleen qi deficiency by regulating intestinal microbes and flora metabolites.Arabian Journal of Chemistry, 2023 Nov 9, 16(11):105232

(5) Luo J, Wu YX, Ma LT, Zhang MY, Li FT, Cai YY, Zheng F*, Yue H. Immunomodulatory effect of Liangyi paste on the gut microbiota of mice. J Pharm Biomed Anal. 2023 Nov 30;236:115706.

(6) Zhang M, Pi Y, Ma L, Li F, Luo J, Cai Y, Wu Y, Liu M, Dai Y, Zheng F*, Yue H. Effects of ginseng on short-chain fatty acids and intestinal microbiota in rats with spleen-qi deficiency based on gas chromatography-mass spectrometry and 16s rRNA technology. Rapid Commun Mass Spectrom. 2023 Dec 15;37(23):e9640.

(7) Fengyuan, S., Di, Y., Dongyue, Z., Yulin, D., Zifeng, P., Fei, Z., & Hao, Y. (2023). Preparation of solid dispersion of Dushen decoction and establishment of its evaluation method. Chinese Journal of Analytical Chemistry. 2023 October 51;10, 100259

(8) Li, F., Pi, Y., Zhang, M., Ma, L., Wu, Y., Luo, J., Cai, Y., Dai, Y., Zheng, F*., & Yue, H*. (2023). Urine and serum metabolomics study of wild ginseng in rats with spleen-qi deficiency using rapid resolution liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. Journal of separation science, 46(17), e2300344.

(9) Wen L, Miao X, Ding J, Tong X, Wu Y, He Y*, Zheng F*. Pesticides as a risk factor for cognitive impairment: Natural substances are expected to become alternative measures to prevent and improve cognitive impairment. Front Nutr. 2023 Feb 24;10:1113099.

(10) Liu Ming,Li Fangtong,Cai Yongyu,Xie Dong,Wu Yongxi,Zhang Meiyu,Wang Yizhu,Dai Yulin,Zheng Fei*,Yue Hao*. Intervention effects of ginseng on spleen-qi deficiency in rats revealed by GC-MS-based metabonomic approach.[J]. Journal of pharmaceutical and biomedical analysis,2022,217.

(11) Wang Yizhu,Cai Yongyu,Li Fangtong,Zhang Meiyu,Wu Yongxi,Dai Yulin,Zheng Fei*,Yue Hao*,Bai Bing. Effects of Scutellaria baicalensis Georgi. on intestinal flora in rats with spleen deficiency and damp-heat.[J]. Journal of pharmaceutical and biomedical analysis,2022,217.  

(12) Wu Yongxi,Cai Yongyu,Ma Liting,Li Fangtong,Zhang Meiyu,Wang Yizhu,Zheng Fei*,Pi Zifeng*,Yue Hao. Identification and chemical profiling of anti-alcoholic liver disease biomarkers of ginseng Huang jiu using UPLC-Q-Orbitrap-HRMS and network pharmacology-based analyses [J]. Frontiers in Nutrition,2022,9.

(13) Tao, XY; Wu, YX; Li, X; Li, FT; Dai, YL; ZF*; Yue H*. Investigation of the protection from liver injury and pharmacokinetics of baijiu with fermented ginseng in rat and zebrafish model[J]. Chinese Journal of Analytical Chemistry, 2022, 50（11）, 100068

(14) Ming Liu，Yongyu Cai， Fangtong Li， Yongxi Wu，Meiyu Zhang，Yizhu Wang， Meiling Fan， Bo Li， Xin Huang，Fei Zheng*，Hao Yue*.Metabolomics and network pharmacological analysis to explore the mechanism of ginseng treatment for spleen-qi deficiency. Journal of separation science，2022;1-12.

(15) Yongxi Wu, Liting Ma, Yongyu Cai, Fangtong Li, Jing Luo, Bing Bai, Yulin Dai, Fei Zheng*, Zifeng Pi*, Hao Yue. Ginseng fermentation solution is associated with immune response in lung adenocarcinoma by modulating the differential expression of the m7G regulators. Journal of Functional Foods，2022， 99:105337.

(16) Fei Zheng, Huanxi Zhao, Nan Wang, Peng Zhong, Kailu Zhou and Shanshan Yu. Cloning and characterization of thermophilic endoglucanase and its application in the transformation of ginsenosides. AMB Express,2022,12:136.

(17) Zheng, F，Wang, YZ，Wu, YX，Zhang, MY，Li, FT，He, Y，Wen, LK，Yue, H*. Effect of stabilization malvids anthocyanins on the gut microbiota in mice with oxidative stress. J Food Biochem. 2021;00:e13943.

(18) Zheng, F，Xue, H，Wang, BX，Wu, MY，Chen, DX，Yue, H，Wen, LK*，He, Y*. Identification of Stabilization of Malvid Anthocyanins and Antioxidant Stress Activation via the AMPK/SIRT1 Signaling Pathway. Evid Based Complement Alternat Med. 2021:9934646.

(19) Meiyu Zhang, Yizhu Wang, Yongxi Wu, Fangtong Li, Mingxin Han , Yulin Dai, Fei Zheng*, Hao Yue*.Evidence-Based Complementary and Alternative Medicine. 2021:1735803.

(20) Zhang M, Wang Y, Wu Y, Li F, Han M, Dai Y, Zheng F*, Yue H*. In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora. Evid Based Complement Alternat Med. 2021 Oct 22;2021:1735803.

(21) Fang-Tong Li, Di Yang, Feng-Yuan Song, Ming Liu, Yu-Lin Dai, Fei Zheng* and Hao Yue*. In Vitro Effects of Ginseng and the Seed of Zizyphus jujuba var. spinosa on Gut Microbiota of Rats with Spleen Deficiency. Chem. Biodiversity, 2020,17(9): e2000199

(22) Fang-Tong Li, Di Yang, Feng-Yuan Song, Ming Liu, Yu-Lin Dai, Fei Zheng*, Hao Yue*. In vitro effects of ginseng and Ziziphi Spinosae Semen on gut microbiota of rats with spleen deficiency. Chemistry & Biodiversity. 2020, 17（9）,2.408

(23) Zheng F, Han M, He Y, Zhang Y, Liu S, Yue H, Wen L. Biotransformation of anthocyanins from Vitis amurensis Rupr of "Beibinghong" extract by human intestinal microbiota. Xenobiotica. 2019 Sep;49(9):1025-1032.、

(24) Li, Jing, Zai-shang Li and Fei Zheng. Nobiletin Inhibits Proliferation, Invasion, Migration and Angiogenesis in Colorectal Cancer Cells. Journal of Biomaterials and Tissue Engineering. 2019: 9(5):662-667.

(25) Zheng, Fei，Zhang, Mei-Yu，Wu, Yong-Xi， Wang, Yi-Zhu，Li, Fang-Tong，Han, Ming-Xin，Dai, Yu-Lin，Yue, Hao*. Biotransformation of Ginsenosides (Rb1, Rb2, Rb3, Rc) in Human Intestinal Bacteria and Its Effect on Intestinal Flora. Chem. Biodiversity 2019, 18, e202100296.

(26) 刘明,张美玉,吴泳锡,王一竹,孙玥琦,刘智,郑飞,越皓.参藿五味颗粒制备工艺及其质量标准研究[J].中成药,2022,44(07):2107-2114.

(27) 吴泳锡，张美玉，王一竹，李方彤，刘明，戴雨霖，郑飞*，越皓*.基于GC-MS 和LC-MS 的人参冰酒成分分析. 质谱学报, 2022,43(2):189-200.

(28) 张美玉，吴泳锡，王一竹，李方彤，刘明，戴雨霖，郑飞*，越皓*. 补气中药通过调节肠道菌群治疗脾虚证的研究进展. 中草药. 2021，52（17），5430-5436

(29) 越皓,周东月,张美玉, 张琰, 戴雨霖,郑飞*,朱英豪*. 红参中原人参三醇型皂苷组在肠道菌群中体外转化及对肠道菌群的作用.应用化学，2021,38(3):323-330.

(30) 刘明,宋凤媛,李方彤,杨迪,越皓,戴雨霖,郑飞*,黄鑫*.天然产物与肠道微生物相互作用的研究进展[J].应用化学,2021,38(04):367-375.

(31) 张琰，李方彤，韩铭鑫，郑飞*，越皓*. 通过RRLC-Q-TOF MS和UPLC-QQQ MS分析原人参三醇型皂苷在人肠道菌群中的代谢产物.质谱学报 2020，41（1），66-75

(32) 杨迪,李方彤,刘明,宋凤媛,葛岩,戴雨霖,郑飞*,越皓*.基于UPLC Orbitrap MS/MS分析锦灯笼中化学成分.质谱学报,2021,42(3):253-260I0002

(33) 蔡泳昱,吴泳锡,李方彤,谢东,王一竹,张美玉,戴雨霖,郑飞*,越皓*.肠道菌群及其代谢产物与神经退行性疾病关系研究进展.应用化学,2023,40(3):309-316

(34) 韩铭鑫,李方彤,张琰,戴雨霖,郑飞*,越皓*.稀有原人参二醇型皂苷的人肠道菌群生物转化. 高等学校化学学报, 2019, 40(7): 1390.

(35) 郑飞,张琰,韩铭鑫,乔梦丹,戴雨霖,越皓,刘淑莹*.RRLC-Q-TOF MS法分析鲜人参与仙人掌果配伍发酵前后人参皂苷成分的变化.质谱学报,2018,39(5):532-539

(36) 乔梦丹,于珊珊,刘尚,戴雨霖,越皓*,郑飞*,郭云龙.UPLC-TSQ-Endure质谱分析Rg3对2型糖尿病大鼠P450酶活性的影响[J].分析试验室,2018,(1):21-25.

(37) 郑飞,韩铭鑫,贺阳,等.仙参果酒体内外抗氧化活性的研究.食品研究与开发, 2018, 39(17):6.

(38) 郑飞, 鲁文慧, 杨波, 杨辛欣, & 张炜煜. (2020). 思政元素融入药剂学课程教学研究.

二、授权专利

1.一种雾化给药系统

2. 中药药物分析信息系统 V1.0

3.新型给药过程控制系统 V1.0

4.林下参有效成分分析信息系统 V1.0

5.原产地中药材品质评价辨识系统 V1.0

6.一种稳定化锦葵 3-O-葡萄糖苷衍生物及其制备方法与应用